Welcome to PRECOS

PRECOS aims to become the leading pre-clinical research and development partner of healthcare companies with a specific focus on oncology, through innovation, technology and service.

 

 

Precos Oncology Preclinical CRO services and development contract testing

Background to PRECOS

PRECOS is a contract research organisation (CRO), which offers specialised services in preclinical, oncology testing. Our aim is to provide your project with all the expert support it needs from early research, through development to the clinic.

PRECOS evolved from the Academic Unit of Cancer Studies, which has been at the forefront of preclinical oncology research for over a decade. PRECOS can therefore offer an established track record in preclinical oncology testing that includes the research and development of oncology therapies at various stages of drug development. Several of these oncology therapies have progressed through preclinical testing to the clinic.

PRECOS Contract Research Organisation (CRO) Services

At the cutting edge of preclinical oncology, PRECOS offers flexible contract research services, which can be tailored to the research and development of your oncology therapy.

  • PRECOS scientists can collaborate either as stand-alone services or as part of an integrated research programme, offering ongoing advice on development issues as they arise.
  • PRECOS will ensure that specific research objectives are defined and that testing is rapidly progressed to generate high quality preclinical data facilitating a more accurate projection of the results for development of the oncology treatment to the clinic.
  • Your research and development programme will be managed by a dedicated Project Co-ordinator to ensure the services provided meets your needs.

PRECOS Preclinical Oncology Expertise

The PRECOS scientists are experts in the field of preclinical oncology and provide services tailored to your research programme. The flexible contract research services offered by PRECOS allow testing to be performed as one-off services or a complete preclinical research programme.

PRECOS also benefits from an established academic multi disciplinary skills base, which adds to its services, by providing clients with additional expertise in the testing of oncology therapies and the development of effective research programmes.

PRECOS Specialised Oncology Research and Development Testing

As part of the CRO service offered, PRECOS scientists have developed, optimised and evaluated a range of solutions to preclinical oncology testing challenges. PRECOS scientists can assist in the selection of appropriate testing for optimal drug evaluation throughout the research and development programme.

PRECOS offers high quality services, such that all testing is performed in accordance with best scientific practise. The research of PRECOS scientists is of the highest standards as it is continually included in and peer-reviewed by regulatory bodies and key oncology journals.

PRECOS Research and Development Programmes

The search for novel treatments in oncology encompasses a range of design and implementation challenges. The service offered by PRECOS allows you to obtain advice from experts in preclinical oncology, at any stage of your research and development programme. Assistance can be given in the formulation of research objectives, testing of the novel oncology therapy and scientific interpretation of the data.

Collaboration and communication are key to a successful research and development programme and are fundamental principles within PRECOS. Expert scientists will work in partnership with you on the design of individual protocols or entire research programmes to facilitate the development of your oncology therapy. Ongoing data feedback maximises the flow of information, allowing efficient progression through the research programme. The flexibility of the preclinical oncology services provided by PRECOS allows the research programme to be updated as necessary ensuring the development process is not hindered. The overall process will be managed by a dedicated Project Co-ordinator.

PRECOS Preclinical Oncology Contract Research Services

The expert team at PRECOS offer a complete range of preclinical oncology testing including histochemical services, in vitro and in vivo research and development and molecular biology services.

PRECOS strives to be at the forefront of the development of new technologies in order to become the leading preclinical research and development partner of healthcare companies, with a specific focus on oncology.

Histochemical Services

The standard histochemical services provided by PRECOS are much enhanced by the use of Quantitative Computer Aided Image Analysis, designed by the PRECOS scientists. This advanced technology can be applied in the research and development of the following areas

  • Angiogenesis.
  • Assessment of proliferation and cell death.
  • Histology.

In addition to these services, PRECOS can assist in the development of specialised histochemical techniques tailored to meet the specific testing needs of your research programme.

In Vitro Research and Development

PRECOS offers medium throughput multi-compound screening services in over 100 human, mouse and rat cell lines, including unique human colorectal, gastric, pancreatic and oesophageal cell lines.

PRECOS in vitro research and development assays provide highly reproducible results, rapid data production and multiple drug screening and can be offered as stand-alone services or in support of a wider research programme.

The testing methods offered by this CRO include:

  • Cell proliferation and viability assays.
  • Apoptosis assays.
  • Radioligand assays
  • Diagnostic/biomarker detection.

In addition to these services, PRECOS can assist in the development of specialised in vitro testing tailored to meet the specific testing needs of your research programme.

In Vivo Research and Development

PRECOS scientists have developed, optimised and evaluated an extensive panel of in vivo models relevant to each aspect of cancer progression, encompassing pre-cancerous lesions, primary tumours and metastasis. PRECOS services include expert assistance in the selection of appropriate cell line and model systems for optimal oncology therapy evaluation, proof of concept or mechanism of action testing.

To support a particular oncology speciality, PRECOS can also collaborate in the research and development of specific models for testing novel oncology therapies.

The in vivo research and development services offered by PRECOS include:

  • Unique patient-relevant disseminated tumour models.
  • Orthotopic and metastatic models.
  • Industry standard xenogeneic and syngeneic tumour models.
  • Tumour localisation studies.

PRECOS conforms to both the spirit and the recommendations of the United Kingdom Coordinating Committee for Cancer Research (UKCCCR) guidelines. The principles of Reduction, Refinement and Replacement are actively pursued during preclinical oncology research.

Molecular Biology Services

At the cutting edge of molecular biology, PRECOS can offer collaborative research to investigate the role of genes in malignancy. The contract research services provided include:

• Real time PCR.
• Interfering RNA.
• Gene cloning and stable transfection.
• Gene reporter assays.

PRECOS Expert Contract Research Preclinical Oncology Testing and Services

PRECOS strives to be at the forefront of the development of new technologies in order to become the leading preclinical research and development partner of healthcare companies, with a specific focus on oncology.

PRECOS, a CRO specialising in preclinical oncology, works with you at any stage of your research and development programme, offering stand-alone services and testing or practical assistance and ongoing advice in your full research programme.

 

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